| County | American Indian Percentage of Total Population |
| Shannon |  86.8 |
| Todd | 81.0 |
| Buffalo | 80.8 |
| Dewey | 72.7 |
| Ziebach | 71.3 |
| Corson | 64.0 |
| Mellette | 54.3 |
| Bennett | 54.2 |
| Jackson | 51.2 |
| Lyman | 36.9 |
| Charles Mix | 31.1 |
| Roberts | 31.1 |
| Walworth | 13.1 |
| Moody | 11.8 |
| Tripp | 11.7 |
| Hughes | 10.7 |
| Day | 10.2 |
| Brule | 9.8 |
| Hyde | 8.7 |
| Marshall | 8.1 |
| Pennington | 7.5 |
| Stanley | 6.9 |
| Gregory | 6.9 |
| Fall River | 6.3 |
| Bon Homme | 4.3 |
| Custer | 3.7 |
| Jones | 3.7 |
| Clay | 3.3 |
| Haakon | 3.0 |
| Brown | 2.9 |
| Lawrence | 2.4 |
| Davison | 2.3 |
| Minnehaha | 2.2 |
| Aurora | 2.1 |
| Meade | 2.1 |
| Yankton | 1.9 |
| Perkins | 1.9 |
| Butte | 1.9 |
| Spink | 1.8 |
| Codington | 1.7 |
| Beadle | 1.5 |
| Douglas | 1.4 |
| Harding | 1.3 |
| Sully | 1.2 |
| Potter | 1.2 |
| Brookings | 1.1 |
| Lake | 1.0 |
| Deuel | 1.0 |
| Jerauld | 0.9 |
| Grant | 0.8 |
| Clark | 0.8 |
| Hutchinson | 0.8 |
| Hamlin | 0.7 |
| Lincoln | 0.6 |
| Turner | 0.6 |
| Union | 0.6 |
| Kingsbury | 0.5 |
| Sanborn | 0.5 |
| Campbell | 0.5 |
| McPherson | 0.5 |
| Miner | 0.4 |
| McCook | 0.4 |
| Edmunds | 0.3 |
| Faulk | 0.3 |
| Hand | 0.2 |
| Hanson | 0.2 |