| County | American Indian Population |
| Greenville |  2,334 |
| York | 1,877 |
| Charleston | 1,826 |
| Horry | 1,692 |
| Richland | 1,575 |
| Lexington | 1,351 |
| Berkeley | 1,329 |
| Marlboro | 1,294 |
| Spartanburg | 1,154 |
| Dorchester | 997 |
| Dillon | 881 |
| Aiken | 816 |
| Beaufort | 672 |
| Anderson | 568 |
| Florence | 552 |
| Orangeburg | 548 |
| Sumter | 433 |
| Pickens | 359 |
| Greenwood | 349 |
| Chesterfield | 323 |
| Lancaster | 317 |
| Colleton | 306 |
| Newberry | 301 |
| Saluda | 279 |
| Cherokee | 279 |
| Kershaw | 249 |
| Oconee | 224 |
| Darlington | 205 |
| Laurens | 199 |
| Marion | 194 |
| Georgetown | 181 |
| Chester | 163 |
| Jasper | 155 |
| Williamsburg | 134 |
| Barnwell | 111 |
| Edgefield | 106 |
| Clarendon | 103 |
| Calhoun | 90 |
| Hampton | 83 |
| Abbeville | 75 |
| Fairfield | 70 |
| Bamberg | 63 |
| Union | 57 |
| Lee | 56 |
| Allendale | 20 |
| McCormick | 20 |